<p>This entry groups metazoan phosphatidylethanolamine-binding proteins, carboxypeptidase Y inhibitor from <taxon tax_id="4932">Saccharomyces cerevisiae</taxon> (Baker's yeast) (<db_xref db="SWISSPROT" dbkey="P14306"/>), and homologues from plants which function in flower development. The members of this family belong to MEROPS proteinase inhibitor family I51, clan I-. </p><p>In metazoa the phosphatidylethanolamine-binding proteins are an around 200 residue and found in a variety of tissues [<cite idref="PUB00003436"/>]. They bind hydrophobic ligands, such as phosphatidylethanolamine, but also seems [<cite idref="PUB00001689"/>] to bind nucleotides such as GTP and FMN, it has been suggested that they could act in membrane remodelling during growth and maturation.</p> <p>In plants, the phosphatidylethanolamine-binding protein homologues, include:</p> <ul><li> CENTRORADIALIS (CEN) [<cite idref="PUB00015036"/>]</li><li> SELF PRUNING (SP) [<cite idref="PUB00015037"/>] </li><li> TERMINAL FLOWER 1 (TFL1) </li><li> FLOWERING LOCUS T (FT) </li><li> MOTHER OF FT AND TFL1 (MTF) [<cite idref="PUB00015038"/>]</li></ul><p>In <taxon tax_id="3702">Arabidopsis thaliana</taxon> (Mouse-ear cress), FT together with LEAFY (LFY), <db_xref db="INTERPRO" dbkey="IPR002910"/>, promote flowering and are positively regulated by the transcription factor CONSTANS (CO), <db_xref db="INTERPRO" dbkey="IPR002926"/>. Loss of FT causes delay in flowering, whereas over expression of FT results in precocious flowering independent of CO or photoperiod. FT acts in part downstream of CO and mediates signals for flowering in an antagonistic manner with its homologous gene, TERMINAL FLOWER1 (TFL1) [<cite idref="PUB00015039"/>].</p>