<p>Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site [<cite idref="PUB00012777"/>]. </p><p>This entry represents a structural subdomain found at the C-termimus of the Methusela ectodomain.</p>