Electron transfer flavoprotein, FixA subunit, predicted

Electron transfer flavoprotein, FixA subunit, predicted(InterPro Protein Domain record)

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Electron transfer flavoprotein, FixA subunit, predicted

InterPro Protein Domain record

description http://metadb.riken.jp/db/SciNetS_rib124i/prib124u1i

Electron transfer flavoproteins (ETFs) serve as specific electron acceptors for primary dehydrogenases, transferring the electrons to terminal respiratory systems. They can be functionally classified into constitutive, "housekeeping" ETFs, mainly involved in the oxidation of fatty acids (Group I), and ETFs produced by some prokaryotes under specific growth conditions, receiving electrons only from the oxidation of specific substrates (Group II) [<cite idref="PUB00033231"/>]. ETFs are heterodimeric proteins composed of an alpha and beta subunit, and contain an FAD cofactor and AMP [<cite idref="PUB00004936"/>, <cite idref="PUB00005086"/>, <cite idref="PUB00004879"/>, <cite idref="PUB00024527"/>, <cite idref="PUB00033232"/>]. ETF consists of three domains: domains I and II are formed by the N- and C-terminal portions of the alpha subunit, respectively, while domain III is formed by the beta subunit. Domains I and III share an almost identical alpha-beta-alpha sandwich fold, while domain II forms an alpha-beta-alpha sandwich similar to that of bacterial flavodoxins. FAD is bound in a cleft between domains II and III, while domain III binds the AMP molecule. Interactions between domains I and III stabilise the protein, forming a shallow bowl where domain II resides.The alpha subunit of both Group I and Group II ETFs is composed of domains I and II.Many enterobacteria are are able to convert carnitine, via crotonobetaine, to gamma-butyrobetaine in the presence of carbon and nitrogen sources under anaerobic conditions [<cite idref="PUB00053911"/>]. In Escherichia coli the enzymes involved in this pathway are encoded by the caiTABCDE operon [<cite idref="PUB00003866"/>]. The adjacent but divergent fixABCD operon also appears to be necessary for carnintine meatbolism [<cite idref="PUB00054253"/>]. The Fix proteins are homologous to proteins found in known electron transport pathways.This entry represents the predicted electron transfer protein beta subunit FixA, which is necessary for anaerobic carnitine reduction. FixA may be involved in transferring reductant to the CaiA protein.

label http://www.w3.org/2000/01/rdf-schema#label