<p> The formation of isosinate, a precursor of adenylate and guanylate, from 5-phosphoribosyl 1-pyrophosphate in the de novo purine biosynthesis pathway isbasically composed of 10 steps of reactions [<cite idref="PUB00033185"/>]. Phosphoribosylglycinamide formyltransferase 2 (<db_xref db="EC" dbkey="2.1.2"/>) is an alternative enzyme to phosphoribosylglycinamide formyltransferase that catalyzes the third step in the de novo purine biosynthesis pathway.</p>