<p> A beta barrel of circularly permuted topology is found in the C terminus of many translation elongation and initiation factors. This domain is found in the elongation factors EF1A (or EF-Tu) of both eukaryotes and prokaryotes, which functions to recognise and transport aminoacyl-tRNA to the acceptor (A) site of the ribosome during the elongation process [<cite idref="PUB00011834"/>, <cite idref="PUB00011832"/>]. This domain is also found in the initiation factor IF2 gamma subunit of eukaryotes [<cite idref="PUB00011835"/>], which functions to transport the initiator methionyl-tRNA to the ribosome. The C-terminal extension of mitochondrial EF1A (or EF-Tu) has structural similarities with DNA recognising zinc fingers, suggesting that the extension may be involved in recognition of RNA.</p><p>More information about EF1A proteins can be found at Protein of the Month: Elongation Factors [<cite idref="PUB00033962"/>].</p>