Mitochondrial Rho proteins (Miro-1, Swiss:Q8IXI2, and Miro-2,Swiss:Q8IXI1), are atypical Rho GTPases. They have a uniquedomain organisation, with tandem GTP-binding domains and two EFhand domains (Pfam:PF00036), that may bind calcium. They arealso larger than classical small GTPases. It has been proposedthat they are involved in mitochondrial homeostasis andapoptosis [1][2].