C57BL/6-TgH(Zic1)

http://metadb.riken.jp/db/rikenbrc_mouse/RBRC00702

Zic genes encode zinc finger proteins. These genes are homologs of the Drosophila pair-rule gene odd-paired. This strain was developed to clarify the function of Zic1 gene. Homozygous Zic1 deficient mice show remarkable ataxia during postnatal development, and die within 1 month. Their cerebella are hypoplastic and missing a lobule in the anterior lobe. A bromodeoxyuridine labeling study indicated a reduction both in the proliferating cell fraction in the external germinal layer (EGL), from embryonic day14, and in forward movement of the EGL (Aruga J et al. J Neurosci 18, 284-293, 1998).