English Statistics Help FAQ Contact Us
Download >>

PDBj (Protein Data Bank Japan) maintains a centralized PDB archive of macromolecular structures and provides integrated tools, in collaboration with the RCSB, the BMRB in USA and the PDBe in EU. PDBj is supported by JST-NBDC and Osaka University.

Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

More images...
View in 3D molecule viewer
( jV3 / Jmol ) *1
PDB ID1gxf  sequence information (FASTA format)   
RELATED PDB ID1aog, 1nda
DescriptorTRYPANOTHIONE REDUCTASE (OXIDIZED FORM) (E.C.1.6.4.8)
TitleCRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH THE INHIBITOR QUINACRINE MUSTARD
Functional KeywordsOXIDOREDUCTASE, TRYPANOTHIONE REDUCTASE, FAD DEPENDENT, DISULPHIDE OXIDOREDUCTASE, QUINACRINE MUSTARD, INHIBITOR, REDOX-ACTIVE CENTER, FLAVOPROTEIN, FAD, NADP
Biological sourceTRYPANOSOMA CRUZI
Cellular location [UNP - P28593] Cytoplasm
Total number of polymer chains2
Total molecular weight111415.5 (the details in Structural Details Page)
AuthorsBond, C.S. , Peterson, M.R. , Vickers, T.J. , Fairlamb, A.H. , Hunter, W.N. (deposition date : 2002-04-04, release date : 2004-05-06)
Primary citationSaravanamuthu, A. , Vickers, T.J. , Bond, C.S. , Peterson, M.R. , Hunter, W.N. , Fairlamb, A.H.
Two Interacting Binding Sites for Quinacrine Derivatives in the Active Site of Trypanothione Reductase: A Template for Drug Design
J.Biol.Chem., 279:29493 - , 2004.(PubMed : 15102853)  (DOI: 10.1074/JBC.M403187200)
Experimental methodX-RAY DIFFRACTION ( 2.70[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P28593 ) , eF-site , KEGG ( EC 1.6.4.8 ) , PISA