PDB ID 1h23 sequence information (FASTA format)
RELATED PDB ID 1acj , 1acl , 1amn , 1ax9 , 1cfj , 1dx6 , 1e3q , 1e66 , 1ea5 , 1eea , 1eve , 1fss , 1gpk , 1gpn , 1gqr , 1gqs , 1hbj , 1h22 , 1jjb , 1oce , 1qid , 1qie , 1qif , 1qig , 1qih , 1qii , 1qij , 1qik , 1qim , 1qti , 1som , 1vot , 1vxo , 1vxr , 2ace , 2ack , 2dfp , 3ace , 4ace
Descriptor ACETYLCHOLINESTERASE (E.C.3.1.1.7)
Title STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH (S,S)-(-)-BIS(12)-HUPYRIDONE AT 2.15A RESOLUTION
Functional Keywords SERINE HYDROLASE, ACETYLCHOLINESTERASE, NEUROTRANSMITTER CLEAVAGE, ALZHEIMER'S DISEASE, BIVALENT LIGAND, DUAL-SITE BINDING, INHIBITOR, HUPERZINE A, HYDROLASE, SERINE ESTERASE SYNAPSE, MEMBRANE, NERVE, MUSCLE, SIGNAL, GPI-ANCHOR NEUROTRANSMITTER DEGRADATION, GLYCOPROTEIN, BIS(12)-HUPYRID
Biological source TORPEDO CALIFORNICA
(PACIFIC ELECTRIC RAY)
Cellular location
[UNP - P04058 ]
Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein
Organ source ELECTRIC ORGAN
Total number of polymer chains 1
Total molecular weight 62262.9 (the details in Structural Details Page )
Authors Wong, D.M. , Greenblatt, H.M. , Carlier, P.R. , Han, Y.F. , Pang, Y.P. , Silman, I. , Sussman, J.L.
(deposition date : 2002-07-30, release date : 2002-12-23)
Primary citation Wong, D.M. , Greenblatt, H.M. , Dvir, H. , Carlier, P.R. , Han, Y.F. , Pang, Y.P. , Silman, I. , Sussman, J.L.J.Am.Chem.Soc. ,
125:363 - , 2003.(PubMed : 12517147) (DOI: 10.1021/JA021111W)
Experimental method X-RAY DIFFRACTION ( 2.15[Å] )
Other Database Information
