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MineSummary [1hzh]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID1hzh  sequence information (FASTA format)   
DescriptorIMMUNOGLOBULIN (HEAVY CHAIN, LIGHT CHAIN)
TitleCRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN
Functional Keywordsimmunoglobulin, antibody, b12, IMMUNE SYSTEM
Biological sourceHomo sapiens (human)
Total number of polymer chains6
Total molecular weight151630.4 (the details in Structural Details Page)
AuthorsSaphire, E.O. , Burton, D.R. , Wilson, I.A. (deposition date : 2001-01-24, release date : 2001-08-15)
Primary citationSaphire, E.O. , Parren, P.W. , Pantophlet, R. , Zwick, M.B. , Morris, G.M. , Rudd, P.M. , Dwek, R.A. , Stanfield, R.L. , Burton, D.R. , Wilson, I.A.
Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design.
Science, 293:1155 - 1159, 2001.(PubMed : 11498595)  (DOI: 10.1126/science.1061692)
Experimental methodX-RAY DIFFRACTION ( 2.70[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , GenBank/DDBJ/EMBL (GB - 567141, GB - 185362, GB - 567142, GB - 2894829) , eF-site , PISA