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MineSummary [1iei]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
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PDB ID1iei  sequence information (FASTA format)   
DescriptorALDOSE REDUCTASE(E.C.1.1.1.21), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [3-(4-BROMO-2-FLUORO-BENZYL)-7-CHLORO-2,4-DIOXO-3,4-DIHYDRO-2H-QUINAZOLIN-1-YL]-ACETIC ACID
TitleCRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE INHIBITOR ZENARESTAT.
Functional KeywordsProtein-inhibitor complex, NADP, OXIDOREDUCTASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P15121] Cytoplasm
Organ source [UNP - P15121] Placenta
[UNP - P15121] Fetus
[UNP - P15121] Lymphoma
[UNP - P15121] Brain, Eye, and Urinary bladder
[UNP - P15121] Brain, and Cajal-Retzius cell
[UNP - P15121] Muscle
Total number of polymer chains1
Total molecular weight37083.7 (the details in Structural Details Page)
AuthorsKinoshita, T. , Miyake, H. , Fujii, T. , Takakura, S. , Goto, T. (deposition date : 2001-04-09, release date : 2002-04-10)
Primary citationKinoshita, T. , Miyake, H. , Fujii, T. , Takakura, S. , Goto, T.
The structure of human recombinant aldose reductase complexed with the potent inhibitor zenarestat.
Acta Crystallogr., D58:622 - 626, 2002.(PubMed : 11914486)  (DOI: 10.1107/S0907444902002378)
Experimental methodX-RAY DIFFRACTION ( 2.5[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P15121 ) , eF-site , KEGG ( EC 1.1.1.21 ) , PISA