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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID1j3k  sequence information (FASTA format)   
RELATED PDB ID1j3i, 1j3j
DescriptorBifunctional dihydrofolate reductase (E.C.1.5.1.3)-thymidylate synthase (E.C.2.1.1.45)
TitleQuadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP
Functional Keywordsbifunctional, OXIDOREDUCTASE, TRANSFERASE
Biological sourcePlasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains4
Total molecular weight146750.2 (the details in Structural Details Page)
AuthorsYuvaniyama, J. , Chitnumsub, P. , Kamchonwongpaisan, S. , Vanichtanankul, J. , Sirawaraporn, W. , Taylor, P. , Walkinshaw, M. , Yuthavong, Y. (deposition date : 2003-02-03, release date : 2003-05-06)
Primary citationYuvaniyama, J. , Chitnumsub, P. , Kamchonwongpaisan, S. , Vanichtanankul, J. , Sirawaraporn, W. , Taylor, P. , Walkinshaw, M.D. , Yuthavong, Y.
Insights into antifolate resistance from malarial DHFR-TS structures.
Nature Struct. Biol., 10:357 - 365, 2003.(PubMed : 12704428)  (DOI: 10.1038/nsb921)
Experimental methodX-RAY DIFFRACTION ( 2.10[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P13922 ) , eF-site , KEGG ( EC 1.5.1.3, 2.1.1.45 ) , PISA