PDB ID 1awf sequence information (FASTA format)
Descriptor ALPHA THROMBIN, HIRUGEN, R3-ACETOXY-17-(1-FORMYL-5-METHYL-3-OXO-HEX-4-ENYL)-12,16-DIHYDROXY-14-HYDROXYMETHYL-4,10,13-TRIMETHYL-2,3,4,5,6,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE-4-CARBOXYLIC ACID IDOPYRANOSYL ESTER
Title NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT
Functional Keywords PROTEINASE, BLOOD COAGULATION, TRYPSIN LIKE PROTEINASE, COMPLEX (PROTEASE/INHIBITOR)
Biological source Homo sapiens
(human)
,Hirudo medicinalis
(medicinal leech)
(the details in Structural Details Page )
Cellular location
[UNP - P00734 ]
Secreted, extracellular space
Organ source BLOOD
Total number of polymer chains 3
Total molecular weight 35977.3 (the details in Structural Details Page )
Authors Jhoti, H. , Cleasby, A. , Wonacott, A.
(deposition date : 1997-10-02, release date : 1998-10-28)
Primary citation Weir, M.P. , Bethell, S.S. , Cleasby, A. , Campbell, C.J. , Dennis, R.J. , Dix, C.J. , Finch, H. , Jhoti, H. , Mooney, C.J. , Patel, S. , Tang, C.M. , Ward, M. , Wonacott, A.J. , Wharton, C.W.Biochemistry ,
37:6645 - 6657, 1998.(PubMed : 9578548) (DOI: 10.1021/bi972499o)
Experimental method X-RAY DIFFRACTION ( 2.2[Å] )
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