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<Asymmetric unit>
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PDB ID1jd0  sequence information (FASTA format)   
Descriptorcarbonic anhydrase XII (E.C.4.2.1.1)
TitleCRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CARBONIC ANHYDRASE XII COMPLEXED WITH ACETAZOLAMIDE
Functional KeywordsExtracellular Domain, Human Carbonic Anhydrase XII, bitopic membrane protein, TYPE I MEMBRANE PROTEIN, LYASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - O43570] Membrane; Single-pass type I membrane protein
Organ source [UNP - O43570] Renal cell carcinoma
[UNP - O43570] Lung
[UNP - O43570] Eye, and Kidney
Total number of polymer chains2
Total molecular weight60290 (the details in Structural Details Page)
AuthorsWhittington, D.A. , Waheed, A. , Ulmasov, B. , Shah, G.N. , Grubb, J.H. , Sly, W.S. , Christianson, D.W. (deposition date : 2001-06-11, release date : 2001-08-17)
Primary citationWhittington, D.A. , Waheed, A. , Ulmasov, B. , Shah, G.N. , Grubb, J.H. , Sly, W.S. , Christianson, D.W.
Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.
Proc. Natl. Acad. Sci. U.S.A., 98:9545 - 9550, 2001.(PubMed : 11493685)  (DOI: 10.1073/pnas.161301298)
Experimental methodX-RAY DIFFRACTION ( 1.50[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( O43570 ) , eF-site , KEGG ( EC 4.2.1.1 ) , PISA