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MineSummary [1kfl]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>

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PDB ID1kfl  sequence information (FASTA format)   
RELATED PDB ID1qr7, 1gg1
Descriptor3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (E.C.4.1.2.15)
TitleCrystal structure of phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase) from E.coli complexed with Mn2+, PEP, and Phe
Functional Keywordsbeta/alpha barrel, allosteric inhibition, feedback regulation, aromatic biosynthetic pathway, LYASE
Biological sourceEscherichia coli
Total number of polymer chains8
Total molecular weight312122.4 (the details in Structural Details Page)
AuthorsShumilin, I.A. , Zhao, C. , Bauerle, R. , Kretsinger, R.H. (deposition date : 2001-11-21, release date : 2002-08-23)
Primary citationShumilin, I.A. , Zhao, C. , Bauerle, R. , Kretsinger, R.H.
Allosteric inhibition of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase alters the coordination of both substrates.
J. Mol. Biol., 320:1147 - 1156, 2002.(PubMed : 12126632)  (DOI: 10.1016/S0022-2836(02)00545-4)
Experimental methodX-RAY DIFFRACTION ( 2.8[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P0AB91 ) , eF-site , KEGG ( EC 4.1.2.15 ) , PISA