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MineSummary [1l2i]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID1l2i  sequence information (FASTA format)   
RELATED PDB ID3erd, 1l2j
DescriptorESTROGEN RECEPTOR, glucocorticoid receptor interacting protein 1
TitleHuman Estrogen Receptor alpha Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol and a Glucocorticoid Receptor Interacting Protein 1 NR box II Peptide
Functional Keywordsnuclear receptor, transcription factor, estrogen, agonist, coactivator, TRANSCRIPTION RECEPTOR/COACTIVATOR COMPLEX
Biological sourceHomo sapiens (human)
Cellular location [UNP - P03372] Nucleus
Organ source [UNP - P03372] Mammary gland
[UNP - P03372] Mammary carcinoma
[UNP - Q61026] Brain
[UNP - Q61026] Embryo
[UNP - Q61026] Liver
Total number of polymer chains4
Total molecular weight63652.9 (the details in Structural Details Page)
AuthorsShiau, A.K. , Barstad, D. , Radek, J.T. , Meyers, M.J. , Nettles, K.W. , Katzenellenbogen, B.S. , Katzenellenbogen, J.A. , Agard, D.A. , Greene, G.L. (deposition date : 2002-02-21, release date : 2002-05-01)
Primary citationShiau, A.K. , Barstad, D. , Radek, J.T. , Meyers, M.J. , Nettles, K.W. , Katzenellenbogen, B.S. , Katzenellenbogen, J.A. , Agard, D.A. , Greene, G.L.
Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.
Nature Struct. Biol., 9:359 - 364, 2002.(PubMed : 11953755)
Experimental methodX-RAY DIFFRACTION ( 1.95[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P03372, Q61026 ) , eF-site , PISA