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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID2fz9  sequence information (FASTA format)   
RELATED PDB ID2fz8, 1mar, 2fzb, 2fzd
Descriptoraldose reductase (E.C.1.1.1.21)
TitleHuman Aldose Reductase complexed with inhibitor zopolrestat after six days soaking.
Functional KeywordsTIM barrel, backbone flip, OXIDOREDUCTASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P15121] Cytoplasm
Organ source [UNP - P15121] Placenta
[UNP - P15121] Fetus
[UNP - P15121] Lymphoma
[UNP - P15121] Brain, Eye, and Urinary bladder
[UNP - P15121] Brain, and Cajal-Retzius cell
[UNP - P15121] Muscle
Total number of polymer chains1
Total molecular weight37061.5 (the details in Structural Details Page)
AuthorsSteuber, H. , Zentgraf, M. , Gerlach, C. , Sotriffer, C.A. , Heine, A. , Klebe, G. (deposition date : 2006-02-09, release date : 2006-10-03)
Primary citationSteuber, H. , Zentgraf, M. , Gerlach, C. , Sotriffer, C.A. , Heine, A. , Klebe, G.
Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions.
J.Mol.Biol., 363:174 - 187, 2006.(PubMed : 16952371)  (DOI: 10.1016/j.jmb.2006.08.011)
Experimental methodX-RAY DIFFRACTION ( 1.60[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P15121 ) , eF-site , KEGG ( EC 1.1.1.21 ) , PISA