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MineSummary [1me4]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID1me4  sequence information (FASTA format)   
RELATED PDB ID1f29, 1f2a, 1f2c, 1f2b
DescriptorCruzaine (E.C.3.4.22.-)
TitleHigh Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I)
Functional Keywordscysteine protease, non-covalent inhibitor, Hydrolase
Biological sourceTrypanosoma cruzi
Total number of polymer chains1
Total molecular weight23175.8 (the details in Structural Details Page)
AuthorsBrinen, L.S. , Huang, L. , Ellman, J.A. (deposition date : 2002-08-07, release date : 2002-12-18)
Primary citationHuang, L. , Brinen, L.S. , Ellman, J.A.
Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain
Bioorg.Med.Chem., 11:21 - 29, 2003.(PubMed : 12467703)  (DOI: 10.1016/S0968-0896(02)00427-3)
Experimental methodX-RAY DIFFRACTION ( 1.2[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P25779 ) , eF-site , KEGG (EC 3.4.22.- ) , PISA