PDB ID 1o3g sequence information (FASTA format)
RELATED PDB ID 1c5r
Descriptor BETA-TRYPSIN (E.C.3.4.21.4)
Title Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
Functional Keywords serine protease, short hydrogen bond, inhibition mechanism, shift of pKa, trypsin, thrombin, urokinase, factor Xa, hydrolase
Biological source Bos taurus
(cattle)
Cellular location
[UNP - P00760 ]
Secreted, extracellular space
Organ source PANCREAS
Total number of polymer chains 1
Total molecular weight 23727.4 (the details in Structural Details Page )
Authors Katz, B.A. , Elrod, K. , Verner, E. , Mackman, R.L. , Luong, C. , Shrader, W.D. , Sendzik, M. , Spencer, J.R. , Sprengeler, P.A. , Kolesnikov, A. , Tai, V.W. , Hui, H.C. , Breitenbucher, J.G. , Allen, D. , Janc, J.W.
(deposition date : 2003-03-06, release date : 2003-09-02)
Primary citation Katz, B.A. , Elrod, K. , Verner, E. , Mackman, R.L. , Luong, C. , Shrader, W.D. , Sendzik, M. , Spencer, J.R. , Sprengeler, P.A. , Kolesnikov, A. , Tai, V.W. , Hui, H.C. , Breitenbucher, J.G. , Allen, D. , Janc, J.W.J.Mol.Biol. ,
329:93 - 120, 2003.(PubMed : 12742021) (DOI: 10.1016/S0022-2836(03)00399-1)
Experimental method X-RAY DIFFRACTION ( 1.55[Å] )
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