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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID1o6h  sequence information (FASTA format)   
RELATED PDB ID1gsz, 1h35, 1h36, 1h37, 1h39, 1h3a, 1h3b, 1h3c, 1o6q, 1o6r, 1o79, 1ump, 1sqc, 2sqc, 3sqc
DescriptorSQUALENE--HOPENE CYCLASE (E.C.5.4.99.-)
TitleSQUALENE-HOPENE CYCLASE
Functional KeywordsISOMERASE, CHOLESTEROL BIOSYNTHESIS, INHIBITOR, INTERACTIONS, OXIDOSQUALENE CYCLASE, MONOTOPIC MEMBRANE PROTEIN
Biological sourceALICYCLOBACILLUS ACIDOCALDARIUS
Cellular location [UNP - P33247] Cell membrane; Peripheral membrane protein
Total number of polymer chains3
Total molecular weight217231.5 (the details in Structural Details Page)
AuthorsLenhart, A. , Reinert, D.J. , Weihofen, W.A. , Aebi, J.D. , Dehmlow, H. , Morand, O.H. , Schulz, G.E. (deposition date : 2002-10-03, release date : 2003-10-02)
Primary citationLenhart, A. , Reinert, D.J. , Aebi, J.D. , Dehmlow, H. , Morand, O.H. , Schulz, G.E.
Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46:2083 - , 2003.(PubMed : 12747780)  (DOI: 10.1021/JM0211218)
Experimental methodX-RAY DIFFRACTION ( 2.8[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P33247 ) , eF-site , KEGG (EC 5.4.99.- ) , PISA