PDB ID 1o6h sequence information (FASTA format)
RELATED PDB ID 1gsz , 1h35 , 1h36 , 1h37 , 1h39 , 1h3a , 1h3b , 1h3c , 1o6q , 1o6r , 1o79 , 1ump , 1sqc , 2sqc , 3sqc
Descriptor SQUALENE--HOPENE CYCLASE (E.C.5.4.99.-)
Title SQUALENE-HOPENE CYCLASE
Functional Keywords ISOMERASE, CHOLESTEROL BIOSYNTHESIS, INHIBITOR, INTERACTIONS, OXIDOSQUALENE CYCLASE, MONOTOPIC MEMBRANE PROTEIN
Biological source ALICYCLOBACILLUS ACIDOCALDARIUS
Cellular location
[UNP - P33247 ]
Cell membrane; Peripheral membrane protein
Total number of polymer chains 3
Total molecular weight 217231.5 (the details in Structural Details Page )
Authors Lenhart, A. , Reinert, D.J. , Weihofen, W.A. , Aebi, J.D. , Dehmlow, H. , Morand, O.H. , Schulz, G.E.
(deposition date : 2002-10-03, release date : 2003-10-02)
Primary citation Lenhart, A. , Reinert, D.J. , Aebi, J.D. , Dehmlow, H. , Morand, O.H. , Schulz, G.E. Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem. ,
46:2083 - , 2003.(PubMed : 12747780) (DOI: 10.1021/JM0211218)
Experimental method X-RAY DIFFRACTION ( 2.8[Å] )
Other Database Information