PDB ID 1n9a sequence information (FASTA format)
RELATED PDB ID 1n94 , 1n95
Descriptor Protein farnesyltransferase alpha subunit (E.C.2.5.1.-), Protein farnesyltransferase beta subunit (E.C.2.5.1.-)
Title Farnesyltransferase complex with tetrahydropyridine inhibitors
Functional Keywords Farnesyltransferase, tetrahydropyridine, Prenyltransferase TRANSFERASE
Biological source Rattus norvegicus
(Norway rat)
Organ source
[UNP - Q04631 ]
Brain
Total number of polymer chains 2
Total molecular weight 83825.2 (the details in Structural Details Page )
Authors Gwaltney II, S.L. , O'Conner, S.J. , Nelson, L.T. , Sullivan, G.M. , Imade, H. , Wang, W. , Hasvold, L. , Li, Q. , Cohen, J. , Gu, W.Z.
(deposition date : 2002-11-22, release date : 2003-01-07)
Primary citation Gwaltney II, S.L. , O'Connor, S.J. , Nelson, L.T.J. , Sullivan, G.M. , Imade, H. , Wang, W. , Hasvold, L. , Li, Q. , Cohen, J. , Gu, W.Z. , Tahir, S.K. , Bauch, J. , Marsh, K. , Ng, S.C. , Frost, D.J. , Zhang, H. , Muchmore, S. , Jakob, C.G. , Stoll, V. , Hutchins, C. , Rosenberg, S.H. , Sham, H.L. Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.
Bioorg.Med.Chem.Lett. ,
13:1363 - 1366, 2003.(PubMed : 12657283) (DOI: 10.1016/S0960-894X(03)00094-5)
Experimental method X-RAY DIFFRACTION ( 3.20[Å] )
Other Database Information