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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID1n9a  sequence information (FASTA format)   
RELATED PDB ID1n94, 1n95
DescriptorProtein farnesyltransferase alpha subunit (E.C.2.5.1.-), Protein farnesyltransferase beta subunit (E.C.2.5.1.-)
TitleFarnesyltransferase complex with tetrahydropyridine inhibitors
Functional KeywordsFarnesyltransferase, tetrahydropyridine, Prenyltransferase
TRANSFERASE
Biological sourceRattus norvegicus (Norway rat)
Organ source [UNP - Q04631] Brain
Total number of polymer chains2
Total molecular weight83825.2 (the details in Structural Details Page)
AuthorsGwaltney II, S.L. , O'Conner, S.J. , Nelson, L.T. , Sullivan, G.M. , Imade, H. , Wang, W. , Hasvold, L. , Li, Q. , Cohen, J. , Gu, W.Z. (deposition date : 2002-11-22, release date : 2003-01-07)
Primary citationGwaltney II, S.L. , O'Connor, S.J. , Nelson, L.T.J. , Sullivan, G.M. , Imade, H. , Wang, W. , Hasvold, L. , Li, Q. , Cohen, J. , Gu, W.Z. , Tahir, S.K. , Bauch, J. , Marsh, K. , Ng, S.C. , Frost, D.J. , Zhang, H. , Muchmore, S. , Jakob, C.G. , Stoll, V. , Hutchins, C. , Rosenberg, S.H. , Sham, H.L.
Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.
Bioorg.Med.Chem.Lett., 13:1363 - 1366, 2003.(PubMed : 12657283)  (DOI: 10.1016/S0960-894X(03)00094-5)
Experimental methodX-RAY DIFFRACTION ( 3.20[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q04631, Q02293 ) , eF-site , KEGG (EC 2.5.1.- ) , PISA