PDB ID 1nlj sequence information (FASTA format)
RELATED PDB ID 1atk , 1au0 , 1nl6
Descriptor CATHEPSIN K (E.C.3.4.22.38)
Title CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT AZEPANONE INHIBITOR
Functional Keywords HYDROLASE, SULFHYDRYL PROTEINASE
Biological source Homo sapiens
(human)
Cellular location
[UNP - P43235 ]
Lysosome
Organ source
[UNP - P43235 ]
BloodUNP - P43235 ]
BoneUNP - P43235 ]
OsteoclastomaUNP - P43235 ]
SpleenUNP - P43235 ]
Skin
Total number of polymer chains 2
Total molecular weight 48100.4 (the details in Structural Details Page )
Authors Smith, W.W. , Janson, C.A. , Zhao, B.
(deposition date : 2003-01-07, release date : 2003-01-14)
Primary citation Marquis, R.W. , Ru, Y. , LoCastro, S.M. , Zeng, J. , Yamashita, D.S. , Oh, H.J. , Erhard, K.F. , Davis, L.D. , Tomaszek, T.A. , Tew, D. , Salyers, K. , Proksch, J. , Ward, K. , Smith, B. , Levy, M. , Cummings, M.D. , Haltiwanger, R.C. , Trescher, G. , Wang, B. , Hemling, M.E. , Quinn, C.J. , Cheng, H.Y. , Lin, F. , Smith, W.W. , Janson, C.A. , Zhao, B. , McQueney, M.S. , D'Alessio, K. , Lee, C.P. , Marzulli, A. , Dodds, R.A. , Blake, S. , Hwang, S.M. , James, I.E. , Gress, C.J. , Bradley, B.R. , Lark, M.W. , Gowen, M. , Veber, D.F.J.Med.Chem. ,
44:1380 - 1395, 2001.(PubMed : 11311061) (DOI: 10.1021/jm000481x)
Experimental method X-RAY DIFFRACTION ( 2.4[Å] )
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