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MineSummary [1p5e]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID1p5e  sequence information (FASTA format)   
DescriptorCell division protein kinase 2 (2.7.2.-), Cyclin A2
TitleThe strucure of phospho-CDK2/cyclin A in complex with the inhibitor 4,5,6,7-tetrabromobenzotriazole (TBS)
Functional KeywordsKinase inhibitor, CDK2, TBS, CELL CYCLE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P20248] Nucleus
Organ source [UNP - P24941] Placenta
[UNP - P24941] Epithelium
[UNP - P24941] Lung
[UNP - P20248] Brain
Total number of polymer chains4
Total molecular weight128406.2 (the details in Structural Details Page)
AuthorsDe Moliner, E. , Brown, N.R. , Johnson, L.N. (deposition date : 2003-04-26, release date : 2003-07-01)
Primary citationDe Moliner, E. , Brown, N.R. , Johnson, L.N.
Alternative binding modes of an inhibitor to two different kinases
Eur.J.Biochem., 270:3174 - 3181, 2003.(PubMed : 12869192)  (DOI: 10.1046/j.1432-1033.2003.03697.x)
Experimental methodX-RAY DIFFRACTION ( 2.22[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P24941, P20248 ) , eF-site , KEGG (EC 2.7.1.- ) , PISA