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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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PDB ID1okw  sequence information (FASTA format)   
RELATED PDB ID1aq1, 1b38, 1b39, 1buh, 1ckp, 1di8, 1dm2, 1e1v, 1e1x, 1e9h, 1f5q, 1fin, 1fq1, 1fvt, 1fvv, 1g5s, 1gih, 1gii, 1gij, 1gy3, 1gz8, 1h00, 1h01, 1h06, 1h07, 1h08, 1h0u, 1h0v, 1h0w, 1h1p, 1h1q, 1h1r, 1h1s, 1h24, 1h25, 1h26, 1h27, 1h28, 1hck, 1hcl, 1jst, 1jsu, 1jsv, 1jvp, 1ke5, 1ke6, 1ke7, 1ke8, 1ke9, 1ogu, 1oi9, 1oiq, 1oir, 1oit, 1oiu, 1oiy, 1oku, 1okv, 1p2a, 1p5e, 1pkd, 1qmz, 1ol1, 1ol2
DescriptorCELL DIVISION PROTEIN KINASE 2 (E.C.2.7.1.37), CYCLIN A2, ACE-ARG-ARG-LEU-ASN-FCL-NH2
TitleCYCLIN A BINDING GROOVE INHIBITOR AC-ARG-ARG-LEU-ASN-(M-CL-PHE)-NH2
Functional KeywordsCELL CYCLE, COMPLEX(KINASE/CYCLIN), CYCLIN A, LIGAND EXCHANGE, DRUG DESIGN, PEPTIDOMIMETICS
Biological sourceHOMO SAPIENS (HUMAN)
Organ source [UNP - P24941] Placenta
[UNP - P24941] Epithelium
[UNP - P24941] Lung
Total number of polymer chains6
Total molecular weight129219.6 (the details in Structural Details Page)
AuthorsKontopidis, G. , Andrews, M. , Mcinnes, C. , Cowan, A. , Powers, H. , Innes, L. , Plater, A. , Griffiths, G. , Paterson, D. , Zheleva, D. , Lane, D. , Green, S. , Walkinshaw, M. , Fischer, P. (deposition date : 2003-07-31, release date : 2003-12-11)
Primary citationKontopidis, G. , Andrews, M.J.I. , Mcinnes, C. , Cowan, A. , Powers, H. , Innes, L. , Plater, A. , Griffiths, G. , Paterson, D. , Zheleva, D.I. , Lane, D.P, , Green, S. , Walkinshaw, M.D. , Fischer, P.M.
Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange
Structure, 11:1537 - 1546, 2003.(PubMed : 14656438)  (DOI: 10.1016/J.STR.2003.11.006)
Experimental methodX-RAY DIFFRACTION ( 2.50[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P24941, P20248 ) , eF-site , KEGG ( EC 2.7.1.37 ) , PISA