PDBj (Protein Data Bank Japan) maintains a centralized PDB archive of macromolecular structures and provides integrated tools, in collaboration with the RCSB, the BMRB in USA and the PDBe in EU. PDBj is supported by JST-NBDC and Osaka University.
putative coronavirus nsp2 (3CL-PRO), Inhibitor (substrate-analog: CH2-QLTSNV-Z), METHYLENE GROUP
Title
Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs
Functional Keywords
SARS-CoV, HCoV, CORONAVIRUS, TGEV, hydrolase
Biological source
Transmissible gastroenteritis virus
Cellular location
[UNP - P0C6Y5]
Non-structural protein 3: Membrane; Multi- pass membrane protein (Potential). Non-structural protein 4: Membrane; Multi- pass membrane protein (Potential). Non-structural protein 6: Membrane; Multi- pass membrane protein (Potential). Non-structural protein 7: Cytoplasm, perinuclear region (By similarity). Non-structural protein 8: Cytoplasm, perinuclear region (By similarity). Non-structural protein 9: Cytoplasm, perinuclear region (By similarity). Non-structural protein 10: Cytoplasm, perinuclear region (By similarity). Helicase: Endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Cytoplasm, perinuclear region (By similarity)
Anand, K. , Ziebuhr, J. , Wadhwani, P. , Mesters, J.R. , Hilgenfeld, R.
(deposition date : 2003-05-12, release date : 2003-05-20)
Primary citation
Anand, K. , Ziebuhr, J. , Wadhwani, P. , Mesters, J.R. , Hilgenfeld, R. Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs Science,
300:1763 - 1767, 2003.(PubMed : 12746549)(DOI: 10.1126/science.1085658)
