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<Asymmetric unit>
= <Biological unit>

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PDB ID1pxo  sequence information (FASTA format)   
RELATED PDB ID1aq1, 1b39, 1ckp, 1di8, 1dm2, 1e1v, 1e1x, 1e9h, 1fin, 1fvt, 1fvv, 1g5s, 1gih, 1gii, 1gij, 1gz8, 1hck, 1hcl, 1jsv, 1jvp, 1ke5, 1ke6, 1ke7, 1ke8, 1ke9, 1pxm, 1pxn, 1pxp
DescriptorCell division protein kinase 2 (E.C.2.7.1.-)
TitleHUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR [4-(2-Amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amine
Functional KeywordsPROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, 3D-STRUCTURE.
Biological sourceHomo sapiens (human)
Organ source [UNP - P24941] Placenta
[UNP - P24941] Epithelium
[UNP - P24941] Lung
Total number of polymer chains1
Total molecular weight34305.1 (the details in Structural Details Page)
AuthorsWang, S. , Meades, C. , Wood, G. , Osnowski, A. , Anderson, S. , Yuill, R. , Thomas, M. , Mezna, M. , Jackson, W. , Midgley, C. , Griffiths, G. , McNae, I. , Wu, S.Y. , McInnes, C. , Zheleva, D. , Walkinshaw, M.D. , Fischer, P.M. (deposition date : 2003-07-04, release date : 2004-04-13)
Primary citationWang, S. , Meades, C. , Wood, G. , Osnowski, A. , Anderson, S. , Yuill, R. , Thomas, M. , Mezna, M. , Jackson, W. , Midgley, C. , Griffiths, G. , Fleming, I. , Green, S. , McNae, I. , Wu, S.Y. , McInnes, C. , Zheleva, D. , Walkinshaw, M.D. , Fischer, P.M.
2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.
J.Med.Chem., 47:1662 - 1675, 2004.(PubMed : 15027857)  (DOI: 10.1021/jm0309957)
Experimental methodX-RAY DIFFRACTION ( 1.96[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P24941 ) , eF-site , KEGG (EC 2.7.1.- ) , PISA