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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID1q5o  sequence information (FASTA format)   
RELATED PDB ID1q3e, 1q43
DescriptorPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
TitleHCN2J 443-645 in the presence of cAMP, selenomethionine derivative
Functional KeywordsCNBD, C-LINKER, PACEMAKER, HCN, HCN2, CHANNEL, CYCLIC NUCLEOTIDE, CAP, PKA, cAMP, ION CHANNEL, LIGAND, Transport protein
Biological sourceMus musculus (house mouse)
Cellular location [UNP - O88703] Membrane; Multi-pass membrane protein
Organ sourcebrain
Total number of polymer chains1
Total molecular weight24897.3 (the details in Structural Details Page)
AuthorsZagotta, W.N. , Olivier, N.B. , Black, K.D. , Young, E.C. , Olson, R. , Gouaux, J.E. (deposition date : 2003-08-08, release date : 2003-09-09)
Primary citationZagotta, W.N. , Olivier, N.B. , Black, K.D. , Young, E.C. , Olson, R. , Gouaux, E.
Structural basis for modulation and agonist specificity of HCN pacemaker channels
Nature, 425:200 - 205, 2003.(PubMed : 12968185)  (DOI: 10.1038/nature01922)
Experimental methodX-RAY DIFFRACTION ( 2.3[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( O88703 ) , eF-site , PISA