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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID1r5w  sequence information (FASTA format)   
DescriptorH-2 class II histocompatibility antigen, E-K alpha chain, MHC H2-IE-beta, artificial peptide
TitleEvidence that structural rearrangements and/or flexibility during TCR binding can contribute to T-cell activation
Functional KeywordsTCR, MHC class II, crystal structure, structural rearangement, SIGNALING PROTEIN
Biological sourceMus musculus (house mouse)
Cellular location [UNP - P04224] Membrane; Single-pass type I membrane protein (Potential)
Total number of polymer chains6
Total molecular weight88321.4 (the details in Structural Details Page)
AuthorsKrogsgaard, M. , Prado, N. , Adams, E. , He, X. , Chow, D.C. , Wilson, D.B. , Garcia, K.C. , Davis, M.M. (deposition date : 2003-10-13, release date : 2004-03-02)
Primary citationKrogsgaard, M. , Prado, N. , Adams, E.J. , He, X.L. , Chow, D.C. , Wilson, D.B. , Garcia, K.C. , Davis, M.M.
Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation
Mol. Cell, 12:1367 - 1378, 2003.(PubMed : 14690592)  (DOI: 10.1016/S1097-2765(03)00474-X)
Experimental methodX-RAY DIFFRACTION ( 2.9[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P04224, Q31164 ) , eF-site , PISA