PDB ID 1r5w sequence information (FASTA format)
Descriptor H-2 class II histocompatibility antigen, E-K alpha chain, MHC H2-IE-beta, artificial peptide
Title Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T-cell activation
Functional Keywords TCR, MHC class II, crystal structure, structural rearangement, SIGNALING PROTEIN
Biological source Mus musculus
(house mouse)
Cellular location
[UNP - P04224 ]
Membrane; Single-pass type I membrane protein (Potential)
Total number of polymer chains 6
Total molecular weight 88321.4 (the details in Structural Details Page )
Authors Krogsgaard, M. , Prado, N. , Adams, E. , He, X. , Chow, D.C. , Wilson, D.B. , Garcia, K.C. , Davis, M.M.
(deposition date : 2003-10-13, release date : 2004-03-02)
Primary citation Krogsgaard, M. , Prado, N. , Adams, E.J. , He, X.L. , Chow, D.C. , Wilson, D.B. , Garcia, K.C. , Davis, M.M. Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation
Mol. Cell ,
12:1367 - 1378, 2003.(PubMed : 14690592) (DOI: 10.1016/S1097-2765(03)00474-X)
Experimental method X-RAY DIFFRACTION ( 2.9[Å] )
Other Database Information