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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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PDB ID1rwe  sequence information (FASTA format)   
RELATED PDB ID1mpj
Descriptorinsulin, Insulin
TitleEnhancing the activity of insulin at receptor edge: crystal structure and photo-cross-linking of A8 analogues
Functional KeywordsA8-Histidine human insulin, insulin receptor, HORMONE/GROWTH FACTOR COMPLEX
Biological source [UNP - P01308] Homo sapiens (Human)
Cellular location [UNP - P01308] Secreted
Organ source [UNP - P01308] Pancreas
[UNP - P01308] Blood
Total number of polymer chains4
Total molecular weight12005.3 (the details in Structural Details Page)
AuthorsWan, Z. , Xu, B. , Chu, Y.C. , Li, B. , Nakagawa, S.H. , Qu, Y. , Hu, S.Q. , Katsoyannis, P.G. , Weiss, M.A. (deposition date : 2003-12-16, release date : 2005-02-15)
Primary citationWan, Z. , Xu, B. , Huang, K. , Chu, Y.C. , Li, B. , Nakagawa, S.H. , Qu, Y. , Hu, S.Q. , Katsoyannis, P.G. , Weiss, M.A.
Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
Biochemistry, 43:16119 - 16133, 2004.(PubMed : 15610006)  (DOI: 10.1021/bi048223f)
Experimental methodX-RAY DIFFRACTION ( 1.80[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P01308 ) , eF-site , PISA