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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID1t2c  sequence information (FASTA format)   
RELATED PDB ID1ldg, 1t24, 1t25, 1t26, 1t2e, 1t2f
DescriptorL-lactate dehydrogenase (E.C.1.1.1.27)
TitlePlasmodium falciparum lactate dehydrogenase complexed with NADH
Functional KeywordsBinary complex, OXIDOREDUCTASE
Biological sourcePlasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains1
Total molecular weight35735.4 (the details in Structural Details Page)
AuthorsCameron, A. , Read, J. , Tranter, R. , Winter, V.J. , Sessions, R.B. , Brady, R.L. , Vivas, L. , Easton, A. , Kendrick, H. , Croft, S.L. , Barros, D. , Lavandera, J.L. , Martin, J.J. , Risco, F. , Garcia-Ochoa, S. , Gamo, F.J. , Sanz, L. , Leon, L. , Ruiz, J.R. , Gabarro, R. , Mallo, A. , De Las Heras, F.G. (deposition date : 2004-04-21, release date : 2004-05-11)
Primary citationCameron, A. , Read, J. , Tranter, R. , Winter, V.J. , Sessions, R.B. , Brady, R.L. , Vivas, L. , Easton, A. , Kendrick, H. , Croft, S.L. , Barros, D. , Lavandera, J.L. , Martin, J.J. , Risco, F. , Garcia-Ochoa, S. , Gamo, F.J. , Sanz, L. , Leon, L. , Ruiz, J.R. , Gabarro, R. , Mallo, A. , De Las Heras, F.G.
Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity.
J.Biol.Chem., 279:31429 - 31439, 2004.(PubMed : 15117937)  (DOI: 10.1074/jbc.M402433200)
Experimental methodX-RAY DIFFRACTION ( 2.01[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q27743 ) , eF-site , KEGG ( EC 1.1.1.27 ) , PISA