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MineSummary [1t40]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID1t40  sequence information (FASTA format)   
RELATED PDB ID1t41
DescriptorAldose reductase(E.C.1.1.1.21)
TitleCrystal structure of human aldose reductase complexed with NADP and IDD552 at ph 5
Functional Keywordsaldose reductase, X-ray crystallography, ternary complex, inhibitor binding, OXIDOREDUCTASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P15121] Cytoplasm
Organ source [UNP - P15121] Placenta
[UNP - P15121] Fetus
[UNP - P15121] Lymphoma
[UNP - P15121] Brain, Eye, and Urinary bladder
[UNP - P15121] Brain, and Cajal-Retzius cell
[UNP - P15121] Muscle
Total number of polymer chains1
Total molecular weight37056.4 (the details in Structural Details Page)
AuthorsRuiz, F. , Hazemann, I. , Mitschler, A. , Chevrier, B. , Schneider, T. , Joachimiak, A. , Karplus, M. , Podjarny, A. (deposition date : 2004-04-28, release date : 2004-08-03)
Primary citationRuiz, F. , Hazemann, I. , Mitschler, A. , Joachimiak, A. , Schneider, T. , Karplus, M. , Podjarny, A.
The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48.
Acta Crystallogr.,Sect.D, 60:1347 - 1354, 2004.(PubMed : 15272156)  (DOI: 10.1107/S0907444904011370)
Experimental methodX-RAY DIFFRACTION ( 1.80[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P15121 ) , eF-site , KEGG ( EC 1.1.1.21 ) , PISA