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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID1tg9  sequence information (FASTA format)   
RELATED PDB ID1t9n, 1tb0, 1tbt, 1teq, 1teu, 1tg3, 1th9, 1thk
DescriptorCarbonic anhydrase II (E.C.4.2.1.1)
TitleEffect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
Functional Keywordsproton shuttle carbonic anhydrase metalloenzyme, LYASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P00918] Cytoplasm
Organ source [UNP - P00918] Ovary
Total number of polymer chains1
Total molecular weight29378.7 (the details in Structural Details Page)
AuthorsFisher, Z. , Hernandez Prada, J.A. , Tu, C.K. , Duda, D. , Yoshioka, C. , An, H. , Govindasamy, L. , Silverman, D.N. , McKenna, R. (deposition date : 2004-05-28, release date : 2005-01-25)
Primary citationFisher, Z. , Hernandez Prada, J.A. , Tu, C.K. , Duda, D. , Yoshioka, C. , An, H. , Govindasamy, L. , Silverman, D.N. , McKenna, R.
Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44:1097 - 1105, 2005.(PubMed : 15667203)  (DOI: 10.1021/bi0480279)
Experimental methodX-RAY DIFFRACTION ( 1.90[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P00918 ) , eF-site , KEGG ( EC 4.2.1.1 ) , PISA