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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID1zhl  sequence information (FASTA format)   
RELATED PDB ID1zhk
DescriptorHLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, EBV-peptide LPEPLPQGQLTAY
TitleCrystal structure of HLA-B*3508 presenting 13-mer EBV antigen LPEPLPQGQLTAY
Functional KeywordsT-cell receptor, bulged epitopes, IMMUNE SYSTEM
Biological sourceHomo sapiens (human)
Cellular location [UNP - P30685] Membrane; Single-pass type I membrane protein
[UNP - P61769] Secreted
Organ source [UNP - P30685] Blood
[UNP - P61769] Peripheral blood
[UNP - P61769] Dendritic cell
[UNP - P61769] Leukemia
[UNP - P61769] Trachea
[UNP - P61769] Eye, and Skin
[UNP - P61769] Urine
Total number of polymer chains3
Total molecular weight45159.5 (the details in Structural Details Page)
AuthorsTynan, F.E. , Borg, N.A. , Miles, J.J. , Beddoe, T. , El-Hassen, D. , Silins, S.L. , van Zuylen, W.J. , Purcell, A.W. , Kjer-Nielsen, L. , McCluskey, J. , Burrows, S.R. , Rossjohn, J. (deposition date : 2005-04-26, release date : 2005-05-17)
Primary citationTynan, F.E. , Borg, N.A. , Miles, J.J. , Beddoe, T. , El-Hassen, D. , Silins, S.L. , van Zuylen, W.J. , Purcell, A.W. , Kjer-Nielsen, L. , McCluskey, J. , Burrows, S.R. , Rossjohn, J.
The high resolution structures of highly bulged viral epitopes bound to the major histocompatability class I: Implications for T-cell receptor engagement and T-cell immunodominance
J.Biol.Chem., 280:23900 - 23909, 2005.(PubMed : 15849183)  (DOI: 10.1074/jbc.M503060200)
Experimental methodX-RAY DIFFRACTION ( 1.500[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P30685, P61769 ) , eF-site , PISA