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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID1w8p  sequence information (FASTA format)   
RELATED PDB ID1a7f, 1ai0, 1aiy, 1b9e, 1ben, 1efe, 1ev3, 1ev6, 1evr, 1fu2, 1fub, 1g7a, 1g7b, 1guj, 1hiq, 1his, 1hit, 1hls, 1htv, 1hui, 1iog, 1ioh, 1j73, 1jca, 1jco, 1k3m, 1kmf, 1lkq, 1lnp, 1lph, 1mhi, 1mhj, 1mso, 1os3, 1os4, 1q4v, 1qiy, 1qiz, 1qj0, 1sf1, 1sjt, 1sju, 1t1k, 1t1p, 1t1q, 1trz, 1tyl, 1tym, 1uz9, 1vkt, 1xda, 1xgl, 1zeg, 1zeh, 1znj, 2aiy, 2hiu, 3aiy, 4aiy, 5aiy
DescriptorINSULIN A-CHAIN, INSULIN B-CHAIN
TitleSTRUCTURAL PROPERTIES OF THE B25TYR-NME-B26PHE INSULIN MUTANT.
Functional KeywordsINSULIN, IGF-1, X-RAY STRUCTURE, MUTANTS, HORMONE/GROWTH FACTOR
Biological sourceHOMO SAPIENS
Cellular location [UNP - P01308] Secreted
Organ source [UNP - P01308] Pancreas
[UNP - P01308] Blood
Total number of polymer chains12
Total molecular weight35601.6 (the details in Structural Details Page)
AuthorsZakowa, L. , Au-Alvarez, O. , Dodson, E.J. , Dodson, G.G. , Brzozowski, A.M. (deposition date : 2004-09-24, release date : 2005-02-03)
Primary citationZarkowa, L. , Brynda, J. , Au-Alvarez, O. , Dodson, E.J. , Dodson, G.G. , Whittingham, J.L. , Brzozowski, A.M.
Towards the Insulin-Igf-I Intermediate Structures: Functional and Structural Properties of the B25Tyr-Nme-B26Phe Insulin Mutant.
Biochemistry, 43:16293 - 16300, 2004.(PubMed : 15610023)  (DOI: 10.1021/BI048856U)
Experimental methodX-RAY DIFFRACTION ( 2.08[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P01308 ) , eF-site , PISA