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MineSummary [1a1v]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID1a1v  sequence information (FASTA format)   
DescriptorNS3 PROTEIN/DNA COMPLEX
TitleHEPATITIS C VIRUS NS3 HELICASE DOMAIN COMPLEXED WITH SINGLE STRANDED SDNA
Functional KeywordsHEPATITIS C VIRUS, RNA HELICASE, NONSTRUCTURAL PROTEINS, SINGLE-STRANDED DNA, HYDROLASE/DNA COMPLEX
Biological sourceHepatitis C virus (isolate H)
Cellular location [UNP - P27958] Core protein p21: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Endoplasmic reticulum membrane; Multi- pass membrane protein. Protease NS2-3: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease/NTPase/helicase NS3: Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential)
Total number of polymer chains2
Total molecular weight53735.3 (the details in Structural Details Page)
AuthorsKim, J.L. , Morgenstern, K.A. , Griffith, J.P. , Dwyer, M.D. , Thomson, J.A. , Murcko, M.A. , Lin, C. , Caron, P.R. (deposition date : 1997-12-17, release date : 1999-01-13)
Primary citationKim, J.L. , Morgenstern, K.A. , Griffith, J.P. , Dwyer, M.D. , Thomson, J.A. , Murcko, M.A. , Lin, C. , Caron, P.R.
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding.
Structure, 6:89 - 100, 1998.(PubMed : 9493270)  (DOI: 10.1016/S0969-2126(98)00010-0)
Experimental methodX-RAY DIFFRACTION ( 2.2[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P27958 ) , eF-site , PISA