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MineSummary [1xgd]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID1xgd  sequence information (FASTA format)   
DescriptorAldose reductase (E.C.1.1.1.21)
TitleApo R268A human aldose reductase
Functional KeywordsAKR, AKR1B1, NADPH, diabetes, OXIDOREDUCTASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P15121] Cytoplasm
Organ source [UNP - P15121] Placenta
[UNP - P15121] Fetus
[UNP - P15121] Lymphoma
[UNP - P15121] Brain, Eye, and Urinary bladder
[UNP - P15121] Brain, and Cajal-Retzius cell
[UNP - P15121] Muscle
Total number of polymer chains1
Total molecular weight35681.3 (the details in Structural Details Page)
AuthorsBrownlee, J.M. , Bohren, K.M. , Milne, A.C. , Gabbay, K.H. , Harrison, D.H.T. (deposition date : 2004-09-16, release date : 2005-03-29)
Primary citationBohren, K.M. , Brownlee, J.M. , Milne, A.C. , Gabbay, K.H. , Harrison, D.H.T.
The structure of Apo R268A human aldose reductase: Hinges and latches that control the kinetic mechanism
Biochim.Biophys.Acta, 1748:201 - 212, 2005.(PubMed : 15769597)  (DOI: 10.1016/j.bbapap.2005.01.006)
Experimental methodX-RAY DIFFRACTION ( 2.1[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P15121 ) , eF-site , KEGG ( EC 1.1.1.21 ) , PISA