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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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PDB ID1xgi  sequence information (FASTA format)   
RELATED PDB ID1l2s, 1ke4, 1xgj
DescriptorBeta-lactamase (E.C.3.5.2.6)
TitleAmpC beta-lactamase in complex with 3-(3-nitro-phenylsulfamoyl)-thiophene-2-carboxylic acid
Functional KeywordsAmpC, beta-lactamase, cephalosporinase, serine hydrolase
HYDROLASE
Biological sourceEscherichia coli
Cellular location [UNP - P00811] Periplasm
Total number of polymer chains2
Total molecular weight79504.9 (the details in Structural Details Page)
AuthorsTondi, D. , Morandi, F. , Bonnet, R. , Costi, M.P. , Shoichet, B.K. (deposition date : 2004-09-17, release date : 2005-05-03)
Primary citationTondi, D. , Morandi, F. , Bonnet, R. , Costi, M.P. , Shoichet, B.K.
Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture.
J.Am.Chem.Soc., 127:4632 - 4639, 2005.(PubMed : 15796528)  (DOI: 10.1021/ja042984o)
Experimental methodX-RAY DIFFRACTION ( 1.96[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P00811 ) , eF-site , KEGG ( EC 3.5.2.6 ) , PISA