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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID1xgz  sequence information (FASTA format)   
RELATED PDB ID1xh0, 1xh1, 1xh2
DescriptorAlpha-amylase, pancreatic (E.C.3.2.1.1)
TitleStructure of the N298S variant of human pancreatic alpha-amylase
Functional KeywordsChloride, Amylase, Enzyme, Acarbose, Inhibitor, HYDROLASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P04746] Secreted, extracellular space
Organ source [UNP - P04746] Pancreas
Total number of polymer chains1
Total molecular weight56166.2 (the details in Structural Details Page)
AuthorsMaurus, R. , Begum, A. , Kuo, H.H. , Racaza, A. , Numao, S. , Overall, C.M. , Withers, S.G. , Brayer, G.D. (deposition date : 2004-09-17, release date : 2005-05-24)
Primary citationMaurus, R. , Begum, A. , Kuo, H.H. , Racaza, A. , Numao, S. , Andersen, C. , Tams, J.W. , Vind, J. , Overall, C.M. , Withers, S.G. , Brayer, G.D.
Structural and mechanistic studies of chloride induced activation of human pancreatic alpha-amylase
PROTEIN SCI., 14:743 - 755, 2005.(PubMed : 15722449)  (DOI: 10.1110/ps.041079305)
Experimental methodX-RAY DIFFRACTION ( 2.0[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P04746 ) , eF-site , KEGG ( EC 3.2.1.1 ) , PISA