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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID2ian  sequence information (FASTA format)   
RELATED PDB ID1klu, 1klg, 2ial, 2iam
DescriptorHLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, 15-mer peptide from Triosephosphate isomerase (E.C.5.3.1.1), CD4+ T cell receptor E8 alpha chain, CD4+ T cell receptor E8 beta chain
TitleStructural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR
Functional KeywordsX-ray crystallography, major histocompatibility complex, T cell receptor, T cell stimulation, melanoma, tumor antigen, IMMUNE SYSTEM
Biological sourceHomo sapiens (human)
Cellular location [UNP - P01903] Membrane; Single-pass type I membrane protein
[UNP - P01848] Membrane; Single-pass membrane protein (Potential)
Organ source [UNP - P01903] Blood, and Colon
[UNP - P01903] B-cell
[UNP - P01903] Blood
[UNP - P04229] Cerebellum
[UNP - P60174] Liver
[UNP - P60174] Brain, Kidney, Placenta, Prostate, Skeletal muscle, Skin, and Uterus
[UNP - P60174] Mammary carcinoma
[UNP - P60174] Colon carcinoma
[UNP - P60174] Brain, Cajal-Retzius cell, and Fetal brain cortex
[UNP - P60174] Epithelium
[UNP - P60174] Pituitary
Total number of polymer chains20
Total molecular weight376779.2 (the details in Structural Details Page)
AuthorsDeng, L. , Langley, R.J. , Mariuzza, R.A. (deposition date : 2006-09-08, release date : 2007-04-03)
Primary citationDeng, L. , Langley, R.J. , Brown, P.H. , Xu, G. , Teng, L. , Wang, Q. , Gonzales, M.I. , Callender, G.G. , Nishimura, M.I. , Topalian, S.L. , Mariuzza, R.A.
Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor
Nat.Immunol., 8:398 - 408, 2007.(PubMed : 17334368)  (DOI: 10.1038/ni1447)
Experimental methodX-RAY DIFFRACTION ( 2.80[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P01903, P04229, P60174, P01848, P01850 ) , eF-site , PISA