PDB ID 2id4 sequence information (FASTA format)
Descriptor Kexin (E.C.3.4.21.61), Ac-RERK-CMK inhibitor
Title The 1.9 A structure of Kex2 in complex with an Ac-R-E-R-K-chloromethyl ketone inhibitor.
Functional Keywords KEX2, KEXIN, FURIN, PROPROTEIN, PROHORMONE, CONVERTASE, SUBTILISIN LIKE PROTEASE, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX HYDROLASE/HYDROLASE INHIBITOR
Biological source Saccharomyces cerevisiae
(baker's yeast)
Cellular location
[UNP - P13134 ]
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein
Total number of polymer chains 6
Total molecular weight 113264.7 (the details in Structural Details Page )
Authors Wheatley, J.L. , Holyoak, T.
(deposition date : 2006-09-14, release date : 2007-05-01)
Primary citation Wheatley, J.L. , Holyoak, T. Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2.
Proc.Natl.Acad.Sci.Usa ,
104:6626 - 6631, 2007.(PubMed : 17426142) (DOI: 10.1073/pnas.0701983104)
Experimental method X-RAY DIFFRACTION ( 1.90[Å] )
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