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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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PDB ID2id4  sequence information (FASTA format)   
DescriptorKexin (E.C.3.4.21.61), Ac-RERK-CMK inhibitor
TitleThe 1.9 A structure of Kex2 in complex with an Ac-R-E-R-K-chloromethyl ketone inhibitor.
Functional KeywordsKEX2, KEXIN, FURIN, PROPROTEIN, PROHORMONE, CONVERTASE, SUBTILISIN LIKE PROTEASE, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
HYDROLASE/HYDROLASE INHIBITOR
Biological sourceSaccharomyces cerevisiae (baker's yeast)
Cellular location [UNP - P13134] Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein
Total number of polymer chains6
Total molecular weight113264.7 (the details in Structural Details Page)
AuthorsWheatley, J.L. , Holyoak, T. (deposition date : 2006-09-14, release date : 2007-05-01)
Primary citationWheatley, J.L. , Holyoak, T.
Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2.
Proc.Natl.Acad.Sci.Usa, 104:6626 - 6631, 2007.(PubMed : 17426142)  (DOI: 10.1073/pnas.0701983104)
Experimental methodX-RAY DIFFRACTION ( 1.90[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P13134 ) , eF-site , KEGG ( EC 3.4.21.61 ) , PISA