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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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PDB ID2irw  sequence information (FASTA format)   
RELATED PDB ID2ilt
DescriptorCorticosteroid 11-beta-dehydrogenase isozyme 1 (E.C.1.1.1.146)
TitleHuman 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Ether Inhibitor
Functional KeywordsHSD1, NADP, inhibitor, OXIDOREDUCTASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P28845] Endoplasmic reticulum membrane; Single-pass type II membrane protein
Organ source [UNP - P28845] Testis
[UNP - P28845] Brain
Total number of polymer chains8
Total molecular weight241367.2 (the details in Structural Details Page)
AuthorsLongenecker, K.L. , Patel, J.R , Russell, J. , Qin, W. (deposition date : 2006-10-16, release date : 2007-01-23)
Primary citationPatel, J.R. , Shuai, Q. , Dinges, J. , Winn, M. , Pliushchev, M. , Fung, S. , Monzon, K. , Chiou, W. , Wang, J. , Pan, L. , Wagaw, S. , Engstrom, K. , Kerdesky, F.A. , Longenecker, K. , Judge, R. , Qin, W. , Imade, H.M. , Stolarik, D. , Beno, D.W. , Brune, M. , Chovan, L.E. , Sham, H.L. , Jacobson, P. , Link, J.T.
Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.
Bioorg.Med.Chem.Lett., 17:750 - 755, 2007.(PubMed : 17110106)  (DOI: 10.1016/j.bmcl.2006.10.074)
Experimental methodX-RAY DIFFRACTION ( 3.100[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P28845 ) , eF-site , KEGG ( EC 1.1.1.146 ) , PISA