PDB ID 2isp sequence information (FASTA format)
RELATED PDB ID 2iso
Descriptor Polymerase (DNA directed), beta/DNA Complex, 2'-DEOXY-5'-O-(HYDROXY{[HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]OXY}PHOSPHORYL)GUANOSINE
Title Ternary complex of DNA Polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-methylene triphosphate
Functional Keywords nucleotidyl transferase, DNA polymerase, leaving-group, TRANSFERASE/DNA COMPLEX
Biological source Homo sapiens
(human)
Total number of polymer chains 4
Total molecular weight 48428.3 (the details in Structural Details Page )
Authors Sucato, C.A. , Upton, T.G. , Kashemirov, B.A. , Martinek, V. , Xiang, Y. , Beard, W.A.
(deposition date : 2006-10-18, release date : 2007-01-30)
Primary citation Sucato, C.A. , Upton, T.G. , Kashemirov, B.A. , Batra, V.K. , Martinek, V. , Xiang, Y. , Beard, W.A. , Pedersen, L.C. , Wilson, S.H. , McKenna, C.E. , Florian, J. , Warshel, A. , Goodman, M.F. Modifying the beta,gamma Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase beta.
Biochemistry ,
46:461 - 471, 2007.(PubMed : 17209556) (DOI: 10.1021/bi061517b)
Experimental method X-RAY DIFFRACTION ( 2.20[Å] )
Other Database Information