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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID2nxr  sequence information (FASTA format)   
RELATED PDB ID2nwo, 2nwp, 2nwy, 2nxz, 2nxs, 2nxt
Descriptorcarbonic anhydrase 2 (E.C.4.2.1.1)
TitleStructural effects of hydrophobic mutations on the active site of human carbonic anhydrase II
Functional Keywordsproton transfer, histidine 64, carbonic anhydrase, Lyase
Biological sourceHomo sapiens (human)
Cellular location [UNP - P00918] Cytoplasm
Organ source [UNP - P00918] Ovary
Total number of polymer chains1
Total molecular weight29434.8 (the details in Structural Details Page)
AuthorsFisher, S.Z. , McKenna, R. (deposition date : 2006-11-19, release date : 2007-04-24)
Primary citationFisher, S.Z. , Tu, C.K. , Bhatt, D. , Govindasamy, L. , Agbandje-McKenna, M. , McKenna, R. , Silverman, D.N.
Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46:3803 - 3813, 2007.(PubMed : 17330962)  (DOI: 10.1021/bi602620k)
Experimental methodX-RAY DIFFRACTION ( 1.7[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P00918 ) , eF-site , KEGG ( EC 4.2.1.1 ) , PISA