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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID2h6d  sequence information (FASTA format)   
RELATED PDB ID2f15
Descriptor5'-AMP-activated protein kinase catalytic subunit alpha-2 (E.C.2.7.11.1)
TitleProtein Kinase Domain of the Human 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK alpha-2 chain)
Functional KeywordsATP-binding; Cholesterol biosynthesis; Fatty acid biosynthesis;Kinase; Lipid synthesis; Nucleotide-binding; Phosphorylation; Serine/threonine-protein kinase; Steroid biosynthesis; Sterol biosynthesis; Transferase, Structural Genomics, Structural Genomics Consortium, SGC, SIGNALING PROTEIN, TRANSFERASE, SIGNALING PROTEIN,TRANSFERASE
Biological sourceHomo sapiens (human)
Organ source [UNP - P54646] Heart
[UNP - P54646] Skeletal muscle
Total number of polymer chains1
Total molecular weight31558 (the details in Structural Details Page)
AuthorsLittler, D.R. , Walker, J.R. , Wybenga-Groot, L. , Newman, E.M. , Butler-Cole, C. , Mackenzie, F. , Finerty, P.J. , Weigelt, J. , Sundstrom, M. , Arrowsmith, C.H. , Edwards, A.M. , Bochkarev, A. , Dhe-Paganon, S. , Structural Genomics Consortium (SGC) (deposition date : 2006-05-31, release date : 2006-06-27)
Primary citationLittler, D.R. , Walker, J.R. , Davis, T. , Wybenga-Groot, L.E. , Finerty, P.J. , Newman, E. , Mackenzie, F. , Dhe-Paganon, S.
A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation.
Acta Crystallogr.,Sect.F, 66:143 - 151, 2010.(PubMed : 20124709)  (DOI: 10.1107/S1744309109052543)
Experimental methodX-RAY DIFFRACTION ( 1.85[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P54646 ) , eF-site , KEGG ( EC 2.7.11.1 ) , PISA