PDB ID 2av1 sequence information (FASTA format)
RELATED PDB ID 1duz , 1duy , 2av7
Descriptor HLA class I histocompatibility antigen, A-2 alpha chain precursor, Beta-2-microglobulin, Trans-activating transcriptional regulatory protein
Title Crystal structure of HTLV-1 TAX peptide Bound to Human Class I MHC HLA-A2 with the E63Q and K66A mutations in the heavy chain.
Functional Keywords X-ray, TAX peptide, MHC, mutated HLA-A2, E63Q, K66A, IMMUNE SYSTEM
Biological source Homo sapiens
(human)
Cellular location
[UNP - P01892 ]
Membrane; Single-pass type I membrane protein
[UNP - P61770 ]
Secreted
[UNP - P14079 ]
Nucleus (By similarity)
Organ source
[UNP - P01892 ]
Blood
[UNP - P01892 ]
Platelet
Total number of polymer chains 6
Total molecular weight 91666.8 (the details in Structural Details Page )
Authors Borbulevych, O.Y. , Baker, B.M.
(deposition date : 2005-08-29, release date : 2005-10-18)
Primary citation Gagnon, S.J. , Borbulevych, O.Y. , Davis-Harrison, R.L. , Baxter, T.K. , Clemens, J.R. , Armstrong, K.M. , Turner, R.V. , Damirjian, M. , Biddison, W.E. , Baker, B.M. Unraveling a Hotspot for TCR Recognition on HLA-A2: Evidence Against the Existence of Peptide-independent TCR Binding Determinants.
J.Mol.Biol. ,
353:556 - 573, 2005.(PubMed : 16197958) (DOI: 10.1016/j.jmb.2005.08.024)
Experimental method X-RAY DIFFRACTION ( 1.95[Å] )
Other Database Information