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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID2av1  sequence information (FASTA format)   
RELATED PDB ID1duz, 1duy, 2av7
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain precursor, Beta-2-microglobulin, Trans-activating transcriptional regulatory protein
TitleCrystal structure of HTLV-1 TAX peptide Bound to Human Class I MHC HLA-A2 with the E63Q and K66A mutations in the heavy chain.
Functional KeywordsX-ray, TAX peptide, MHC, mutated HLA-A2, E63Q, K66A, IMMUNE SYSTEM
Biological sourceHomo sapiens (human)
Cellular location [UNP - P01892] Membrane; Single-pass type I membrane protein
[UNP - P61770] Secreted
[UNP - P14079] Nucleus (By similarity)
Organ source [UNP - P01892] Blood
[UNP - P01892] Platelet
Total number of polymer chains6
Total molecular weight91666.8 (the details in Structural Details Page)
AuthorsBorbulevych, O.Y. , Baker, B.M. (deposition date : 2005-08-29, release date : 2005-10-18)
Primary citationGagnon, S.J. , Borbulevych, O.Y. , Davis-Harrison, R.L. , Baxter, T.K. , Clemens, J.R. , Armstrong, K.M. , Turner, R.V. , Damirjian, M. , Biddison, W.E. , Baker, B.M.
Unraveling a Hotspot for TCR Recognition on HLA-A2: Evidence Against the Existence of Peptide-independent TCR Binding Determinants.
J.Mol.Biol., 353:556 - 573, 2005.(PubMed : 16197958)  (DOI: 10.1016/j.jmb.2005.08.024)
Experimental methodX-RAY DIFFRACTION ( 1.95[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P01892, P61770, P14079 ) , eF-site , PISA