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MineSummary [2be5]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID2be5  sequence information (FASTA format)   
RELATED PDB ID1iw7, 1smy, 2a6e, 2a69, 2a68, 2a6h
DescriptorDNA-directed RNA polymerase alpha chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta chain (E.C.2.7.7.6), DNA-directed RNA polymerase beta' chain (E.C.2.7.7.6), RNA polymerase omega chain, RNA polymerase sigma factor rpoD
TitleCrystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin
Functional KeywordsRNA POLYMERASE HOLOENZYME, TAGETITOXIN, ANTIBIOTIC, TRANSCRIPTION REGULATION, RIKEN Structural Genomics/Proteomics Initiative, RSGI, Structural Genomics, TRANSFERASE
Biological sourceThermus thermophilus
Total number of polymer chains12
Total molecular weight854469.4 (the details in Structural Details Page)
AuthorsVassylyev, D.G. , Svetlov, V. , Vassylyeva, M.N. , Perederina, A. , Igarashi, N. , Matsugaki, N. , Wakatsuki, S. , Artsimovitch, I. , RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date : 2005-10-22, release date : 2005-11-08)
Primary citationVassylyev, D.G. , Svetlov, V. , Vassylyeva, M.N. , Perederina, A. , Igarashi, N. , Matsugaki, N. , Wakatsuki, S. , Artsimovitch, I.
Structural basis for transcription inhibition by tagetitoxin
Nat.Struct.Mol.Biol., 12:1086 - 1093, 2005.(PubMed : 16273103)  (DOI: 10.1038/nsmb1015)
Experimental methodX-RAY DIFFRACTION ( 2.40[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q9Z9H6, Q8RQE9, Q8RQE8, Q8RQE7, Q5SKW1 ) , eF-site , KEGG ( EC 2.7.7.6 ) , PISA