PDB ID 2bfd sequence information (FASTA format)
RELATED PDB ID 1dtw , 1ols , 1olu , 1olx , 1u5b , 1v11 , 1v16 , 1v1m , 1v1r , 1wci , 1x7w , 1x7x , 1x7y , 1x7z , 1x80 , 2beu , 2bev , 2bew , 2bfb , 2bfc , 2bfe , 2bff
Descriptor 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT (E.C.1.2.4.4), 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT (E.C.1.2.4.4)
Title REACTIVITY MODULATION OF HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE BY AN INTERNAL MOLECULAR SWITCH
Functional Keywords OXIDOREDUCTASE, KETOACID DEHYDROGENASE, BRANCHED-CHAIN, MULTI- ENZYME COMPLEX, ACYLATION, OXIDATIVE DECARBOXYLATION, MAPLE SYRUP URINE DISEASE, THIAMINE DIPHOSPHATE, PHOSPHORYLATION, CONFORMATIONAL SWITCH, REACTIVITY
Biological source HOMO SAPIENS
(HUMAN)
Cellular location
[UNP - P12694 ]
Mitochondrion matrix
Organ source
[UNP - P12694 ]
Bone marrow, and LungUNP - P12694 ]
LiverUNP - P12694 ]
EpitheliumUNP - P12694 ]
PlateletUNP - P21953 ]
PlacentaUNP - P21953 ]
Eye
Total number of polymer chains 2
Total molecular weight 84102.1 (the details in Structural Details Page )
Authors Machius, M. , Wynn, R.M. , Chuang, J.L. , Tomchick, D.R. , Brautigam, C.A. , Chuang, D.T.
(deposition date : 2004-12-06, release date : 2006-02-16)
Primary citation Machius, M. , Wynn, R.M. , Chuang, J.L. , Li, J. , Kluger, R. , Yu, D. , Tomchick, D.R. , Brautigam, C.A. , Chuang, D.T.Structure ,
14:287 - , 2006.(PubMed : 16472748) (DOI: 10.1016/J.STR.2005.10.009)
Experimental method X-RAY DIFFRACTION ( 1.39[Å] )
Other Database Information
