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MineSummary [2c5x]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID2c5x  sequence information (FASTA format)   
RELATED PDB ID1aq1, 1b38, 1b39, 1buh, 1ckp, 1di8, 1dm2, 1e1v, 1e1x, 1e9h, 1f5q, 1fin, 1fq1, 1fvt, 1fvv, 1g5s, 1gih, 1gii, 1gij, 1gy3, 1gz8, 1h00, 1h01, 1h07, 1h08, 1h0v, 1h0w, 1h1p, 1h1q, 1h1r, 1h1s, 1h24, 1h25, 1h26, 1h27, 1h28, 1hck, 1hcl, 1jst, 1jsu, 1jsv, 1jvp, 1ke5, 1ke6, 1ke7, 1ke8, 1ke9, 1ogu, 1oi9, 1oiq, 1oir, 1oit, 1oiu, 1oiy, 1oku, 1okv, 1okw, 1ol1, 1ol2, 1p2a, 1p5e, 1pf8, 1pkd, 1pw2, 1pxi, 1pxj, 1pxk, 1pxl, 1pxm, 1pxn, 1pxo, 1pxp, 1pye, 1qmz, 1r78, 1urc, 1urw, 1v1k, 1vyw, 1vyz, 1w0x, 1w8c, 1w98, 1wcc, 1y8y, 1y91, 2b52, 2b53, 2b54, 2b55, 2bhe, 2bhh, 2bkz, 2bpm, 2btr, 2bts, 2c4g, 2c5n, 2c5o, 2c5p, 2c5t, 2c5v, 2c5y
DescriptorCELL DIVISION PROTEIN KINASE 2 (E.C.2.7.1.37), CYCLIN A2
TitleDIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN
Functional KeywordsTRANSFERASE/INHIBITOR, INHIBITION, ACTIVE, INACTIVE, CDK2, CELL CYCLE, CELL DIVISION, KINASE, MITOSIS, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, ATP-BINDING, COMPLEX (TRANSFERASE/INHIBITOR)
Biological sourceHOMO SAPIENS (HUMAN)
Cellular location [UNP - P20248] Nucleus
Organ source [UNP - P24941] Placenta
[UNP - P24941] Epithelium
[UNP - P24941] Lung
[UNP - P20248] Brain
Total number of polymer chains4
Total molecular weight128207.6 (the details in Structural Details Page)
AuthorsKontopidis, G. , Mcinnes, C. , Pandalaneni, S.R. , Mcnae, I. , Gibson, D. , Mezna, M. , Thomas, M. , Wood, G. , Wang, S. , Walkinshaw, M.D. , Fischer, P.M. (deposition date : 2005-11-03, release date : 2006-03-01)
Primary citationKontopidis, G. , Mcinnes, C. , Pandalaneni, S.R. , Mcnae, I. , Gibson, D. , Mezna, M. , Thomas, M. , Wood, G. , Wang, S. , Walkinshaw, M.D. , Fischer, P.M.
Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design.
Chem.Biol., 13:201 - , 2006.(PubMed : 16492568)  (DOI: 10.1016/J.CHEMBIOL.2005.11.011)
Experimental methodX-RAY DIFFRACTION ( 2.90[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P24941, P20248 ) , eF-site , KEGG ( EC 2.7.1.37 ) , PISA