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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
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PDB ID1jcq  sequence information (FASTA format)   
RELATED PDB ID1jcr, 1jcs, 1d8d, 1ft1
DescriptorProtein Farnesyltransferase, alpha and beta subunits (E.C.2.5.1.-)
TitleCRYSTAL STRUCTURE OF HUMAN PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYL DIPHOSPHATE AND THE PEPTIDOMIMETIC INHIBITOR L-739,750
Functional KeywordsFTASE, PFT, PFTASE, FT, FPT, FARNESYLTRANSFERASE, FARNESYL TRANSFERASE, FARNESYL PROTEIN TRANSFERASE, CAAX, RAS, CANCER, TUMOR REGRESSION, L-739,750, PEPTIDOMIMETIC, INHIBITOR
Biological sourceHomo sapiens (human)
Organ source [UNP - P49354] Retina
[UNP - P49354] Placenta
[UNP - P49354] Colon, and Lung
Total number of polymer chains2
Total molecular weight95056.1 (the details in Structural Details Page)
AuthorsLong, S.B. , Casey, P.J. , Beese, L.S. (deposition date : 2001-06-11, release date : 2001-11-02)
Primary citationLong, S.B. , Hancock, P.J. , Kral, A.M. , Hellinga, H.W. , Beese, L.S.
The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
Proc. Natl. Acad. Sci. U.S.A., 98:12948 - 12953, 2001.(PubMed : 11687658)  (DOI: 10.1073/pnas.241407898)
Experimental methodX-RAY DIFFRACTION ( 2.30[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P49354, P49356 ) , eF-site , KEGG (EC 2.5.1.- ) , PISA