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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID2dv0  sequence information (FASTA format)   
RELATED PDB ID2fz8, 2fz9, 2dux, 2duz
DescriptorAldose reductase (E.C.1.1.1.21)
TitleHuman Aldose Reductase complexed with zopolrestat after 6 days soaking(6days_soaked_2)
Functional KeywordsTIM barrel, OXIDOREDUCTASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P15121] Cytoplasm
Organ source [UNP - P15121] Placenta
[UNP - P15121] Fetus
[UNP - P15121] Lymphoma
[UNP - P15121] Brain, Eye, and Urinary bladder
[UNP - P15121] Brain, and Cajal-Retzius cell
[UNP - P15121] Muscle
Total number of polymer chains1
Total molecular weight37061.5 (the details in Structural Details Page)
AuthorsSteuber, H. , Heine, A. , Klebe, G. (deposition date : 2006-07-28, release date : 2006-10-03)
Primary citationSteuber, H. , Zentgraf, M. , Gerlach, C. , Sotriffer, C.A. , Heine, A. , Klebe, G.
Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions
J.Mol.Biol., 363:174 - 187, 2006.(PubMed : 16952371)  (DOI: 10.1016/j.jmb.2006.08.011)
Experimental methodX-RAY DIFFRACTION ( 1.62[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P15121 ) , eF-site , KEGG ( EC 1.1.1.21 ) , PISA